Feline lower urinary tract disease FLUTD is one of the most common reasons for the use of antimicrobial drugs in veterinary medicine and is, therefore, an important condition to consider to minimise antimicrobial use and development of antimicrobial resistance (Murphy et al., 2012; Schmitt et al., 2019).
CVS’ Lumbry Park Veterinary Specialists, Axiom Veterinary Laboratories and Finn Pathologists have conducted a study to investigate the prevalent strains of bacteria in feline urine and to understand the culture and sensitivity profiles for cats in the UK.
Bacterial urinary tract infections in cats with FLUTD are estimated to be present in around 8 to 19 percent of cases (Gerber et al., 2005; Sævik et al., 2011; Teichmann-Knorrn et al., 2018).
The prevalence of bacterial strains and their resistance to antibiotics in urine samples from cats in the UK have not been widely reported previously.
This study sought to understand the prevalence of bacterial species isolated from 2,712 urine samples collected via cystocentesis from UK cats.
Findings showed that 15.7 percent of these samples had a positive culture, with Escherichia coli (43.7 percent), other Enterobacterales (26.4 percent) and Enterococcus spp (14.9 percent) being the most common isolates identified.
Antimicrobial susceptibilities and resistance were tested in the study. Notably, Enterococcus species were frequently found to be resistant to multiple antibiotics, and several other isolates demonstrated resistance to frequently used antibiotics.
The data showed Enterococcus spp were much less susceptible to trimethoprim and sulfamethoxazole (TMPS) than have been previously documented (with 94 percent of isolates resistant). Additionally, other Enterobacterales had resistance against cephalosporins and penicillins.
Data surrounding cephalosporin resistance is particularly notable and problematic. Recent data has indeed shown that the cephalosporin cefovecin is a commonly prescribed antibiotic (Weese et al., 2021; Burke et al., 2016) for cats presenting with lower urinary tract disease.
Data in the present study adds to the existing evidence that the use of cephalosporins such as cefovecin may be ineffective in many cases (intrinsic resistance of Enterococcus spp), therefore, should be avoided unless cystocentesis and signalment results support their use.
The inappropriate use of antibiotics for bacterial cystitis could not only be ineffective to manage bacterial cystitis in cats but promote further antimicrobial resistance.
To conduct the study of antimicrobial resistance in cats with FLUTD, urinalysis results from feline urine samples submitted and analysed by Axiom and Finn over a period of 14 months (January 2018 to February 2019) were reviewed.
Urine samples had to have been obtained by cystocentesis and signalment information recorded by their submitting vet.
These samples did not have to come from cats presenting with FLUTD signs and therefore consideration should be given to a different (potentially even more increased) prevalence in cats presenting with LUT signs.
