Dog rabies persists despite low virus prevalence - Veterinary Practice
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Dog rabies persists despite low virus prevalence

A new study led by the University of Glasgow has discovered why rabies remains persistently endemic in affected regions despite attempts to combat the pathogen and an overall low virus prevalence

Dog-mediated rabies, a fatal disease which kills tens of thousands of people in Africa every year, remains persistently endemic in affected regions. That is, despite an overall low virus prevalence and attempts to combat the deadly pathogen.

The findings, from an important new study led by the University of Glasgow and published in Science, are based on information gained from tracing the fatal disease in a population of more than 50,000 dogs in Tanzania from 2002 until 2016.

Dog-mediated rabies is transmitted through bites and scratches – either from dog to dog or dog to human – and is almost 100 percent fatal unless immediately treated with a post-bite course of injections that prevents the infection from taking hold. The deadly zoonotic virus is responsible for tens of thousands of deaths each year, mostly affecting children, particularly in low- and middle-income countries.

The World Health Organization (WHO) leads the collective United Against Rabies to drive progress towards zero human deaths from dog-mediated rabies by 2030 because the disease remains endemic across Africa and Asia. The persistent circulation of rabies at very low prevalence in largely unvaccinated domestic dog populations is an enduring scientific enigma.

Now an international team of researchers, led by Professor Katie Hampson at the University of Glasgow, has revealed new insights into the dynamics of this deadly disease in affected regions. The findings explain how the pathogen can persist at such low levels – less than 0.15 percent of the dog population is infected annually – meaning that it can spread under the radar.

The study found that the mobility and behaviour of individual rabid dogs helps to ensure that the virus can disperse and circulate at such low virus prevalence. The findings showed that a small proportion of infected dogs act as “super spreaders”, travelling more than 10km to bite other animals and bringing new virus lineages to different communities, thereby seeding new outbreaks.

Katie Hampson said: “The virus uses a clever strategy for low level persistence, which makes its dynamics harder to both detect and predict. But these new mechanistic insights also show why scaling up dog vaccination is so necessary.”

To understand the virus dynamics, researchers tracked rabies transmissions, dog population densities, disease incidence and vaccination campaigns in a large population of domestic dogs in Serengeti, Tanzania for more than a decade.

According to the findings, the processes that underpin the persistence and prevalence of rabies operate on scales much smaller than those typically modelled for the disease – often down to the behaviour of a few individual infected dogs.

Over the 14 years, the researchers were able to pinpoint hundreds of introductions from neighbouring villages that were able to sustain circulation across the region. The variability in rabid dog biting behaviour means that most introductions do not take off, but some of the outbreaks that do last for years, illustrating how co-circulation of different rabies virus lineages underpins virus persistence.

Rabies is one of the neglected tropical diseases that predominantly affects poor and vulnerable populations who live in remote rural locations. Approximately 80 percent of human cases occur in rural areas. Although effective treatments exist to prevent the onset of rabies following a bite, they are not readily available or accessible to those in need.

Globally, rabies deaths are severely underreported and children between the ages of 5 to 14 years are the most frequent victims. Managing a rabies exposure, where the average cost of rabies post-exposure vaccination exceeds $100, can be a catastrophic financial burden on affected families, whose average daily income may be as low as $1 to $2 per person.

The paper, “Rabies shows how scale of transmission can enable acute infections to persist at low prevalence” is published in Science. The work was funded by Wellcome.

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