DNA test reporting scheme to combat inherited disease in the Tibetan Terrier - Veterinary Practice
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DNA test reporting scheme to combat inherited disease in the Tibetan Terrier

The Kennel club approves a new DNA test reporting scheme for Pituitary Dwarfism after consultation with Tibetan Terrier health co-ordinator

In a move designed to combat inherited disease in the Tibetan Terrier, The Kennel Club has approved a new official DNA test reporting scheme for Pituitary Dwarfism, following consultation with the breed’s health co-ordinator on behalf of the breed clubs. Results will be recorded with the abbreviation DP-LHX3.

Pituitary Dwarfism is a genetic condition caused by a deficiency of growth hormone. This hormone is produced by the pituitary gland, hence the name “pituitary dwarfism”. Affected puppies may not be noticeably different at birth, but will not grow correctly and can die young.

Affected dogs are smaller than other dogs of the same breed and may remain puppy like in their appearance. Typically, dogs with pituitary dwarfism retain their soft puppy coat, may develop hair loss or have problems with tooth development.

The disease is described as autosomal-recessive. This means that a dog must inherit two copies of an abnormal gene (one from its mother and one from its father) before its health is affected.

Tested dogs will be recorded on The Kennel Club systems as one of the following:

  • Clear:
    the dog does not have any copies of the abnormal gene associated with the disease. The dog is highly unlikely to be clinically affected and will only pass on a normal copy of the gene to a puppy
  • Carrier: the dog has one copy of the normal gene and one copy of the abnormal gene associated with the disease. The dog is highly unlikely to be clinically affected, but may pass one copy of the normal gene, or one copy of the abnormal gene on to a puppy
  • Affected:
    the dog has two copies of the abnormal gene associated with the disease. The dog will likely be clinically affected by the disorder and will pass one copy of the abnormal gene on to any potential offspring

To find out which laboratories The Kennel Club is able to record results from for this test, and which labs will send results directly to The Kennel Club, refer to our page about Pituitary Dwarfism. Please note that this listing is not necessarily comprehensive and other labs may offer the tests. To find out which DNA tests are relevant to your breed, you can visit the kennel club website.

Genetics and Research Manager at The Kennel Club, Joanna Ilska, said: “The Kennel Club constantly reviews DNA testing schemes in conjunction with breed clubs to ensure that breeders are supported with resources which help them to make responsible breeding decisions. The Kennel Club works alongside breed clubs and breed health coordinators in a collaborative effort to improve the health of pedigree dogs and is happy to consider a club’s request to add a new DNA test to its lists. A formal request from the breed’s health coordinator or a majority request from the breed clubs is normally required to do this.”

Test results will be added to the dog’s registration details which will trigger the publication of the result in the next available Breed Records Supplement and also on the Health Test Results Finder on The Kennel Club website.

Results for dogs already tested can also be recorded, but owners will need to submit copies of the DNA certificates themselves. DNA test certificates should be scanned and emailed to health.results@thekennelclub.org.uk.

Owners are reminded that from August 2018, it is mandatory that the dog’s microchip (or tattoo) number is recorded along with either the dog’s registered name or registered number on any DNA certificates. Any test results issued after that date that do not carry these identifying features will not be added to The Kennel Club systems.

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